Abstract:

Primary angle-closure glaucoma (PACG) has a particularly high incidence among Chinese, Indians and Eskimo populations. Studies have shown that family history and race are closely related to the occurrence and development of PACG disease. Some recent Genome-wide association studies (GWAS)  have identified eight candidate genes (PLEKHA7, COL11A1, PCMTD1-ST18, EPDR1, CHAT, GLIS3, FERMT2, DPM2-FAM102) related to PACG, and five loci were determined by the Meta analysis. HGF, MFRP, MMP9, and NOS3 four genes are associated with PACG, and HSP70 is associated with primary angle-closure disease (PACD). Morphologically, anterior chamber depth (ACD) is considered to be significantly correlated within the genome range, but the results are still different in the validation trials. These indicate that the participation of genetic factors in the pathogenesis of PACG is still complicated, and need to be supported by large-scale population genetics research also molecular experiments. This article reviews the current genetic development of PACG and analyzes the current research status. (Int Rev Ophthalmol, 2018, 42:  354-359)